From Dan Campeau...
When I have a leaking pup, First thing I rule out is a Bladder or Kidney infection. If yes, then treat with Antibiotics and then follow up with Dried Cranberry leaf extract to stop recuring infections. Once infection is gone, leaking usually stops.
If it is NOT an infection, I assume it is a hormonal issue that will resolve itself when the bitch goes through her first heat cycle. I have never had a pup that did not get better on their own when they went through first heat cycle.
The only thing I would do as a prophlactic measure on a bitch that shows negative on an infection is to give her Cranberry leaf extract so they do not develop an infection.
I do not treat these girls with any other drugs or supplements,,, I just manage the issue judisciously and know that it is a temporary condition. Put pup in an area that is easily cleaned, wash more blankets, keep them outside during the day if possible.
I NEVER spay my girls before their first heat cycle , If you spay a swissy pup that is NOT leaking presently, they will start as you throw their systems into a state of instant menopause.
In most cases of girls that do NOT have a history of leaking, you will avoid many leaking issues if you wait until your girl has gone through at least one heat cycle.
Most of the leaking issues not attributed to infections are hormonal in nature and will get better with age and going through at least ONE heat cycle.
I recently had a leaking pup that I did a surgery on that is common in humans but not common in dogs and that was a hysterectomy only taking out the Uterus. I left the ovaries in so she would not have to be on replacement hormone therapy or major drugs to control leaking the rest of her life. I will continue to monitor her and let you know how it goes. She is making a wonderful pet and companion and is NOT leaking now.